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Molecular hydrogen is a promising therapeutic agent for pulmonary disease

The study explores the therapeutic potential of hydrogen in treating various lung diseases.

Hydrogen therapy has shown promise in alleviating oxidative stress, inflammation, and tissue damage associated with lung diseases such as acute lung injury (ALI), acute respiratory distress syndrome (ARDS), sepsis-induced acute lung injury (S-ALI), viral pneumonia, ischemia-reperfusion (I/R) injury, chronic obstructive pulmonary disease (COPD), asthma, pulmonary hypertension (PH), and pulmonary fibrosis (PF).

Hydrogen acts as an antioxidant and anti-inflammatory agent, reducing oxidative stress, inflammation, and cell damage in lung tissues. It also modulates various cellular pathways involved in lung injury, including the Nrf2/HO-1 pathway, NF-κB pathway, and PI3K/Akt pathway.

Hydrogen can be administered through inhalation of hydrogen gas, oral intake of hydrogen-rich water, injection of hydrogen saline, and local application as eye drops. Additionally, hydrogen can be designed as nanocrystals for targeted delivery and controlled release.

The study suggests that hydrogen therapy holds promise as a novel therapeutic approach for various lung diseases.

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